Split-Brain Experiments

Split-Brain Experiments Roger Sperry (who won the Nobel prize in 1981) and Michael Gazzaniga are two neuroscientists who studied patients who had surgery to cut the corpus callosum. These studies are called "Split-Brain Experiments". After surgery, these people appeared quite "normal" - they could walk, read, talk, play sports and do all the everyday things they did before surgery. Only after careful experiments that isolated information from reaching one hemisphere, could the real effects of the surgery be determined. Dr. Sperry used a tachistoscope to present visual information to one hemisphere or the other. The tachistoscope requires people to focus on a point in the center of their visual field. Because each half of the visual field projects to the opposite site of the brain (crossing in the optic chiasm), it is possible to project a picture to either the right hemisphere OR the left hemisphere.

So, say a "typical" (language in the LEFT hemisphere) split-brain patient is sitting down, looking straight ahead and is focusing on a dot in the middle of a screen. Then a picture of a spoon is flashed to the right of the dot. The visual information about the spoon crosses in the optic chiasm and ends up in the LEFT HEMISPHERE. When the person is asked what the picture was, the person has no problem identifying the spoon and says "Spoon." However, if the spoon had been flashed to the left of the dot (see the picture), then the visual information would have traveled to the RIGHT HEMISPHERE. Now if the person is asked what the picture was, the person will say that nothing was seen!! But, when this same person is asked to pick out an object using only the LEFT hand, this person will correctly pick out the spoon. This is because touch information from the left hand crosses over to the right hemisphere - the side that "saw" the spoon. However, if the person is again asked what the object is, even when it is in the person's hand, the person will NOT be able to say what it is because the right hemisphere cannot "talk." So, the right hemisphere is not stupid, it just has little ability for language - it is "non-verbal."

Another type of experiment performed with split brain patients uses chimeric figures, like this one to the right. In this figure, the face on the left is a woman and the face on the right is a man. Therefore, if the patient focuses on the dot in the middle of the forehead, the visual information about the woman's face will go to the right cerebral hemisphere and information about the man's face will go to the left hemisphere. When a split brain patient is asked to point to a whole, normal picture of the face that was just seen, the patient will usually pick out the woman's picture (remember, the information about the woman's face went to the RIGHT cerebral hemisphere). However, if the patient is required to say whether the picture was a man or a woman, the patient will SAY that the picture was of a man. Therefore, depending on what the patient is required to do, either the right or left hemisphere will dominate. In this case, when speech is not required, the right hemisphere will dominate for recognition of faces.

Before different types of brain surgery, it is important to identify which cerebral hemisphere is dominant for language so that the neurosurgeon can avoid damaging speech areas. One way to test which hemisphere is dominant for language is with a procedure called the Wada Test. During this test, a fast acting anesthetic called sodium amytal (amobarbital) is injected into the right or left carotid artery. The right artery supplies the right cerebral hemisphere and the left artery supplies the left cerebral hemisphere. Therefore, either the right or left hemisphere can be "put to sleep" temporarily. If the left hemisphere is put to sleep in people who have language ability in the left hemisphere, then when asked to speak, they cannot. However, if the right hemisphere is put to sleep, then these people will be able to speak and answer questions. (Remember too that because the right hemisphere controls muscles on the left side, people will not be able to move the left side of their bodies.)

Another way to test for language representation in the brain is to electrically stimulate the cerebral cortex. A neurosurgeon can place an electrode on various areas of the exposed brain of an awake patient during surgery. The patient can say what he or she feels and thinks. Placement of the electrode on the brain does NOT hurt because the brain itself does not have any receptors for pain. In people who have left side dominance for language, electrical stimulation of various locations on the left cerebral cortex will interfere with speech.